TABLE 1

Toxicity study design

Tox StudyTest DurationTest CompoundDoseSex and No. of AnimalsComments on TK Samples
daysμmol/kg
17Vehicle02M + 2F
AZ’78475002M + 2F2M + 2F satellite animals
10002M + 2F2M + 2F satellite animals
27Vehicle 1a04F
Vehicle 2b04F
AZ’784710004F2F satellite animals
Ml5004F2F satellite animals
20004F2F satellite animals
AZ’42701704F2F satellite animals
5004F2F satellite animals
AZ’4284764F2F satellite animals
2304F2F satellite animals
314AZ’090843510F5F animals for μ-sampling
90010F5F animals for μ-sampling
  • F, female; M, male; TK, toxicokinetics.

  • a Same vehicle as AZ’7847, AZ’4270, and AZ’4284.

  • b Same vehicle as for M1.