Drug | Log D7.4 | A | B | ||
---|---|---|---|---|---|
CLint,u | fuinc | CLint,u | fuinc | ||
μl/min per 1 million cells | 1 million cells/ml | μl/min per 1 million cells | 1 million cells/ml | ||
AZ151 | 2.41 | 40 | 0.72 | 38 (2.0) | 0.78 (0.045) |
Atorvastatin | 1.1 | 25 | 0.90 | 68 (6.1) | 0.33 (0.049) |
CLint,u, unbound intrinsic clearance from hepatocyte incubation; fuinc, fraction unbound in the incubation.