TABLE 2

Toxicokinetic summary of AZ’7847 in toxicity study 1

DoseSex and No. of AnimalsAnticipated AUCther (μMh)aDay 1Day 7AUC0–24/AUCther (ratio)
CmaxAUC0–24CmaxAUC0-24
μMμMhμMμMh
500 (μmol/kg)2M11573840684804.2
500 (μmol/kg)2F11538450394303.7
1000 (μmol/kg)2M11546610NANANA
1000 (μmol/kg)2F115751020NANANA
  • AUC0–24, area under the curve for 24 hours; AUCther, area under plasma concentration time curve needed for therapeutic effect; F, female; M, male; NA, not available.

  • a AUCther (area under plasma concentration time curve needed for therapeutic effect) was based on the assumption that a steady-state concentration (Css) average corresponding to 10 times the whole blood assay IC50 value was needed.