Analysis of anastrozole glucuronidation and UGT mRNA expression levels by UGT1A4 variants
| Variant | Frequency | Anastrozole glucuronidation median (S.D.) | UGT1A4 mRNA median (S.D.) | P for Hardy-Weinberg Equilibrium |
|---|---|---|---|---|
| % | pmol/µg/min | |||
| 70C>A | 0.0007 | |||
| CC | 48 (18.7) | 0.4 (0.6) | 1.4 (1.2) | |
| AC | 26 (28.6) | 0.3 (1.7) | 1.3 (0.5) | |
| AA | 17 (52.7) | 0.8 (1.3) | 1.4 (0.3) | |
| 142T>G | 0.12 | |||
| TT | 38 (41.8) | 0.5 (0.7) | 1.4 (0.2) | |
| TG | 36 (39.6) | 0.3 (1.4) | 1.2 (0.5) | |
| GG | 17 (18.7) | 0.3 (1.5) | 1.2 (0.4) | |
| −36G>A | <0.0001 | |||
| GG | 81 (89) | 0.3 (1.2) | 1.4 (1.4) | |
| AG | 7 (7.7) | 1.0 (1.4) | 1.5 (0.3) | |
| AA | 3 (3.3) | 1.3 (0.6) | 1.5 (0.2) | |
| −163G>A | 0.014 | |||
| GG | 73 (79.3) | 0.4 (1.2) | 1.4 (0.3) | |
| AG | 15 (16.3) | 0.7 (1.5) | 1.1 (0.5) | |
| AA | 4 (4.3) | 0.8 (0.3) | 1.4 (0.1) | |
| −217T>G | 0.0002 | |||
| TT | 80 (87.9) | 0.3 (1.1) | 1.3 (0.3) | |
| TG | 8 (8.8) | 1.5 (1.7) | 1.7 (0.3) | |
| GG | 3 (3.3) | 1.9 (1.2) | 1.7 (0.3) | |
| −219C>T | 0.03 | |||
| CC | 69 (74.2) | 0.4 (1.1) | 1.4 (0.3) | |
| CT | 19 (20.4) | 0.9 (0.7) | 1.0 (0.4) | |
| TT | 5 (5.4) | 1.0 (2.2) | 1.2 (0.6) |