TABLE 4

Percent recovery of radioactivity (± S.D.) following a single 1 mg/kg i.v. dose of [¹⁴C]apixaban to male intact and bile duct-cannulated beagle dogs

Compound and Dose Route	Dog Type	Dose Recovery (% of Dose in 0–72 h Collections)
		Urine	Bile	Feces	Total
[¹⁴C]apixaban (i.v.)^a	BDC, n = 2	13.5, 19.1	29.4, 12.4	42.7, 48.6	85.6, 80.1
[¹⁴C]apixaban (i.v.) and charcoal^a	BDC, n = 2	16.3, 8.1	20.5, 13.1	62.7, 74.4	99.5, 95.6
[¹⁴C]apixaban (i.v.)	Intact, n = 3	9.9 ± 7.9	NA	50.8 ± 8.3	60.7 ± 10.6
[¹⁴C]apixaban (oral)^b	Intact, n = 3	8.8	NA	73.7	82.5

BDC, bile duct cannulation; NA, not available.
↵a A crossover study with dosing separated by 1 week.
↵b Oral dose was 5 mg/kg and collections were 0–168 hours for 3 intact dogs (Zhang et al., 2009a) and listed here for comparison.