Pharmacokinetic parameters (mean ± S.D.) of A-1331480 and A-847082 following a 10-mg single oral dose of ABT-384 with and without ketoconazole (KTZ) in healthy adults.
| A-1331480 (N = 12) | A-847082 (N = 12) | |||||
|---|---|---|---|---|---|---|
| Without KTZ Mean (CV%) | With KTZ Mean (CV%) | Ratioa | Without KTZ Mean (CV%) | With KTZ Mean (CV%) | Ratioa | |
| Cmax (ng/ml) | 26.5 (8.2) | 17.3 (6.0) | 0.68 [0.45–0.93] | 1.12 (0.37) | 9.75 (3.4) | 8.6 [5.0–13] |
| Tmax (h) | 3.17 (0.94) | 46.0 (16) | – | 7.92 (5.9) | 90.0 (37) | – |
| t1/2 (h) | 10.9 (2.8) | 47.1 (20) | – | 36.1 (8.2) | b | – |
| AUC0–168 (ng ⋅ h/ml) | 474 (220) | 1690 (390) | 4.10 [2.2–4.8] | 66.1 (41) | 1330 (460) | 19.7 [10–43] |
| AUC∞ (ng ⋅ h/ml) | 476 (210) | 2100 (560) | 4.93 [2.96–6.42] | 76.7 (45) | b | – |