TABLE 2

Single-dose oral pharmacokinetic parameters of midazolam in SD rats

Data are presented as the mean ± S.E. of three female rats.

MidazolamCmaxTmaxAUCp
μMhh·μM
Alone3.37 ± 1.350.500 ± 0.0003.64 ± 1.21
+Rifampicin, 30 mg/kg2.72 ± 0.500.500 ± 0.0004.04 ± 1.23
+Rifampicin, 100 mg/kg3.53 ± 1.850.500 ± 0.0004.96 ± 2.18
+ABT, 50 mg/kg15.43 ± 2.53a2.33 ± 1.53197 ± 23b
  • a P < 0.05 versus values for the same dosing in the absence of ABT.

  • b P < 0.01 versus values for the same dosing in the absence of ABT.