Kinetic parameters for amitriptyline, imipramine, and diphenhydramine N-glucuronidation in HLM
| High Affinity | Low Affinity | |||
|---|---|---|---|---|
| Km1 | Vmax1 | Km2 | Vmax2 | |
| µM | pmol/min/mg | µM | pmol/min/mg | |
| Amitriptyline | 3.6 ± 1.1 | 270 ± 76 | 390 ± 2.0 | 2000 ± 430 |
| Imipramine | 9.3 ± 2.7 | 270 ± 14 | 370 ± 120 | 1200 ± 12 |
| Diphenhydramine | 9.2 ± 3.1 | 210 ± 110 | 310 ± 120 | 1100 ± 190 |