TABLE 2

Clinical digoxin DDI studies

Inhibitor	Dose	AUC Ratio	C_max Ratio	PK Ratio	[I₁]	[I₂]	Reference
	mg/day			AUC or C_max Ratio	µM	µM
Amiodarone^{^a}	800	1.68	1.84	1.84	2.2	4693	(Robinson et al., 1989)
Amiodarone^{^a}	400	1.63	1.72	1.72	2.5	2347	(Robinson et al., 1989)
Captopril	37.5	1.39	1.59	1.59	0.23	230	(Kirimli et al., 2001)
Carvedilol (female)	12.5	1.24	1	1.24	0.044	64	(Baris et al., 2006)
Carvedilol (male)	12.5	1.56	1.38	1.56	0.044	64	(Baris et al., 2006)
Diltiazem	90	1.4	1.38	1.4	0.489	1596	(Mahgoub et al., 2002)
Diltiazem	180	1.24	1.24	1.24	0.196	798	(Rameis et al., 1984)
Felodipine	2.5	1.43	1.35	1.43	0.0071	26	(Rehnqvist et al., 1987)
Felodipine	5	0.76	1.14	1.14	0.0132	52	(Rehnqvist et al., 1987)
Felodipine	10	1.18	1.35	1.35	0.0256	104	(Rehnqvist et al., 1987)
Felodipine	10	Not available	1.18	1.18	0.0315	104	(Dunselman et al., 1988)
Isradipine	15	1.11	1.26	1.26	0.03	56	(Rodin et al., 1988)
Mibefradil^{^b}	150	1.31	1.41	1.41	2.77	1212	(Siepmann et al., 1995)
Nicardipine	20	1.06	1.06	1.06	0.046	167	(Lessem and Bellinetto, 1983)
Nifedipine	15	1.21	1.01	1.21	0.110	173	(Kirch et al., 1986a)
Nifedipine	30	1.23	1.06	1.23	0.230	347	(Kirch et al., 1986a)
Nifedipine	60	1.18	1.08	1.18	0.460	693	(Kirch et al., 1986a)
Nitrendipine	20	1.15	1.57	1.57	0.115	222	(Kirch et al., 1986b)
Nitrendipine	10	1.09	1.22	1.22	0.030	111	(Kirch et al., 1986b)
Quinidine	600	1.76	1.75	1.76	8.83	8152	(Wanwimolruk et al., 2002)
Quinidine	1200	2.65	2.11	2.65	11.2	16,305	(Hager et al., 1979)
Quinidine	750	Not available	2.65	2.65	3.5	10,191	(Belz et al., 1983)
Ranolazine	2000	1.6	1.46	1.6	8.4	18,712	(Jerling et al., 2005)
Sertraline	200	1.1	1.05	1.1	0.39	2612	(Rapeport et al., 1996).
Telmisartan	120	1.22	1.58	1.58	1.1	933	(Stangier et al., 2000).
Troglitazone	400	1.04	1.05	1.05	3.17	3624	(Loi et al., 1998)
Verapamil	240	1.51	1.44	1.51	1.2	652	(Rodin et al., 1988)
Verapamil	360	Not available	1.61	1.61	0.0577	2932	(Belz et al., 1983)
Verapamil	240	Not available	1.77	1.77	0.0332	1955	(Belz et al., 1983)
Verapamil	240	Not available	1.53	1.53	0.0258	1955	(Doering, 1983)

↵^a Amiodarone: doses are from the same study; 800 mg was dosed for 1 week (maintenance dose) and concentration represents the 1 week dosing and the 400 mg was the next 5 weeks.
↵^b No digoxin clinical DDI study so selected highest mibefradil dose