Experimental Groups | Time | Hepatic Concentrations | Bile Efflux Rates | Perfusate Efflux Rates |
---|---|---|---|---|
min | nmol/g | nmol/min | ||
100 μM RIF in normal livers | 90 | 380 ± 110 | 3.3 ± 1.3 | 216 ± 39 |
105 | 197 ± 64 | 2.3 ± 0.8 | 71 ± 31 | |
100 μM RIF in liver lacking Mrp2 | 90 | 538 ± 215a | 0a | 269 ± 32 |
105 | 270 ± 100a | 0a | 85 ± 7 | |
100 μM RIF and 200 μM BOPTA | 90 | 348 ± 194 | 3.1 ± 0.7 | 244 ± 61 |
105 | 151 ± 44 | 2.3 ± 0.7 | 53 ± 34 | |
10 μM RIF and 200 μM BOPTA | 90 | 103 ± 40 | 0.9 ± 0.2 | 58 ± 9 |
105 | 71 ± 19 | 0.5 ± 0.1 | 26 ± 9 | |
1 μM RIF and 200 μM BOPTA | 90 | 46 ± 24 | 0.2 ± 0.1 | 15 ± 11 |
105 | 22 ± 23 | 0.1 ± 0 1 | 7 ± 6 |
↵a P = 0.05 vs. 100 μM RIF in normal livers (with Mrp2).