TABLE 6

Known OAT3 metabolites

MetaboliteAssayReference
Pomgamoside AUp in Oat3-knockout plasmaThis study
9-Amino-nonanoic acidUp in Oat3-knockout plasmaThis study
Flavin mononucleotideUp in Oat3-knockout plasmaVallon et al., 2008a
ThymidineUp in Oat3-knockout plasmaVallon et al., 2008a
UrateDown in Oat3-knockout urineEraly, 2008
DideoxycytidinemOat3, Xenopus. laevisTruong et al., 2008
17β-estradiol-d-17β-glucuronidemOat3, LLC-PK1Nagata, 2002
Estrone sulfatehOAT3, X. laevisWindass, 2007
Homovanillic acidrOat3, X. laevisMori, 2003
3-Carboxy-4-methyl-5-propyl-2-furanpropionatehOAT3, HEK293Deguchi, 2004
Indoxyl sulfatehOAT3, HEK293Deguchi, 2004
Prostaglandin E2hOAT3, S2 segmentKimura, 2002
Prostaglandin F2ahOAT3, S2 segmentKimura, 2002
Dehydroepiandrosterone sulfatehOAT3, HEK293Ueo, 2005
Genistein-7-O-glucuronidehOAT3, HEK293Wong et al., 2011b
Glycitein-7-O-glucuronidehOAT3, HEK293Wong et al., 2011b
Quercetin-3′-O-glucuronidehOAT3, HEK293Wong et al., 2011b
  • HEK, human embryonic kidney; LLC-PK1, a renal epithelial cell line derived from pig kidneys.