TABLE 3

Pharmacokinetic parameters of pitavastatin (0.3 mg/kg) after single intravenous and oral administration to male cynomolgus monkeys in combination with CsA and RIF

Each value represents the mean ± S.D. of four monkeys. CsA or RIF was administered 4 hours and 1 hour before intravenous and oral administration of pitavastatin, respectively. AUC′, CL_total′, and F_H′ refer to the parameters in the presence of a perpetrator.

	Control		CsA, p.o.		RIF, p.o.
	Pitavastatin, i.v.	Pitavastatin, p.o.	Pitavastatin, i.v.	Pitavastatin, p.o.	Pitavastatin, i.v.	Pitavastatin, p.o.
CL_total (ml/h/kg)	756 ± 156		258 ± 104^b		249 ± 109^b
V_ss (ml/kg)	607 ± 169		388 ± 179		431 ± 181
t_1/2 (h)	3.4 ± 0.6	2.5 ± 0.6	2.4 ± 0.8	3.2 ± 1.3	2.7 ± 0.9	4.5 ± 1.2^a
C_max (ng/ml)		15.0 ± 19.7		135 ± 113^b		314 ± 456^c
T_max (h)		2.3 ± 1.3		4.0 ± 1.6		1.9 ± 1.5
AUC (ng·h/ml)	412 ± 48	72 ± 70	1394 ± 776^b	725 ± 651^c	1578 ± 1151^b	1089 ± 1129^c
F_H		0.62 ± 0.08		0.87 ± 0.05^b		0.88 ± 0.05^b
AUC_po′/AUC_po				10.6 ± 1.4		14.8 ± 2.4
CL_total/CL_total′			3.2 ± 0.9		3.6 ± 1.6
F_H′/F_H				1.4 ± 0.1		1.4 ± 0.1
(F_H′/F_H)·(CL_total/CL_total′)				4.5 ± 1.1		5.0 ± 2.0

↵^a P < 0.05, compared with the control values obtained before CsA or RIF treatment.
↵^b P < 0.01.
↵^c P < 0.001.