Table 4

Simcyp predicted phenacetin PK parameters in the presence or absence of PRN or IPRN

Simulation groupCmaxAUC216-240Fold of AUC change
(ng/ml)(ng*h/ml)
Phenacetin in healthy subject population480028300
Phenacetin in healthy subject population in the presence of PRN6880483001.71
Phenacetin in healthy subject population in the presence of IPRN8670923003.26
Phenacetin in smoker subject population362018100
Phenacetin in smoker subject population in the presence of PRN6150382002.12
Phenacetin in smoker subject population in the presence of IPRN8580904005.01
  • Phenacetin 1400 mg QDx10 and PRN or IPRN 60 mg QDx10 were used in simulation. The Cmax and AUC were taken from last dose to mimic the steady-state.