TABLE 2

Inhibition constants for the inhibition of phthalazine and DACA oxidase activity in guinea pig, rhesus monkey, and HLC by raloxifene

PhthalazineDACA
KisKiiKii/KisKisKiiKii/Kis
μMμM
GPLCNA0.042 ± 0.002NANA0.23 ± 0.017NA
RMLC3.6 ± 2.40.5 ± 0.0270.142.14 ± 0.2461.34 ± 0.10.6
HLCNA0.00087 ± 0.00005aNA0.0023 ± 0.0006bNANA
  • HLC, human liver cytosol; NA, not applicable.

  • a Obach, 2004.

  • b Barr and Jones, 2012.