Pharmacokinetics of phenacetin after coadministration of α-naphthoflavone, PRN, or IPRN
Intravenous doses were as follows: 5 mg/kg phenacetin, 7 mg/kg α-naphthoflavone, 5 mg/kg PRN, and 5 mg/kg IPRN. Results are expressed as the mean ± SD. n = 5.
| Parameter | Vehicle (Negative Control) | PRN | IPRN | α-Naphthoflavone (Positive Control) |
|---|---|---|---|---|
| AUC (µg⋅h/ml) | 1.55 ± 0.19 | 8.24 ± 1.12**## | 8.57 ± 2.39**## | 2.83 ± 0.39** |
| Vss (l/kg) | 1.42 ± 0.22 | 0.91 ± 0.24*# | 1.05 ± 0.18*# | 2.51 ± 1.04 |
| CL (ml/min per kilogram) | 54.33 ± 6.75 | 10.27 ± 1.46**## | 10.15 ± 2.24**## | 29.85 ± 3.86** |
| t1/2 (h) | 0.30 ± 0.015 | 1.02 ± 0.17** | 1.21 ± 0.11** | 0.97 ± 0.40* |
| MRT (h) | 0.31 ± 0.02 | 2.21 ± 0.15**## | 1.81 ± 0.22**## | 0.66 ± 0.06** |
| AUC(M)/AUC(P) | 1.39 ± 0.13 | 0.24 ± 0.03**## | 0.19 ± 0.04**## | 0.61 ± 0.55** |
AUC(M)/AUC(P), exposure ratio of acetaminophen to phenacetin; CL, clearance; MRT, mean residence time.
↵* P < 0.05 compared with the negative control group; **P < 0.01 compared with the negative control group; #P < 0.05 compared with the positive control group; ##P < 0.01 compared with the positive control group.