IVIVC of intrinsic clearance using the rat hepatocyte relay method
| Compounds | In Vivo Rat Intrinsic Clearance | In Vitro Intrinsic Clearance from Rat Hepatocyte Relay Method ± S.D. | Fold Difference In Vivo/Relay Method |
|---|---|---|---|
| ml/min/kg | ml/min/kg | ||
| Caffeine | 4.3 (Nakazawa et al., 1985) | 3.0 ± 0.76 | 1.4 |
| Tolbutamide | 9.9 (Ashforth et al., 1995; Mandula et al., 2006) | 9.8 ± 0.71 | 0.61 |
| Antipyrine | 6.5 (Belpaire et al., 1990) | 2.4 ± 1.35 | 2.7 |
| Famotidine | 9.4 (Matsuzaki et al., 2008) | 6.6 ± 2.31 | 1.4 |
| (±)-Warfarin | 19 (Yacobi and Levy, 1977; Hirate et al., 1990) | 12 ± 0.01 | 1.6 |
| Ranitidine | 20 (Eddershaw et al., 1996) | 18 ± 0.39 | 1.1 |
| Cimetidine | 27 (McPherson and Lee, 1977; Kurata et al., 2010) | 16 ± 1.6 | 1.7 |
| Naproxen | 38 (Huntjens et al., 2006) | 37 ± 5.04 | 1.0 |
| Fexofenadine | 47 (Tahara et al., 2005) | 21 ± 1.41 | 2.3 |
| (±)-Acebutolol | 88 (Piquette-Miller and Jamali, 1997) | 7.9 ± 0.89 | 11 |
| Fluvastatin | 85-154 (Watanabe et al., 2010a) | 54 ± 2.77 | 1.6-2.9 |
| (±)-Ketoprofen | 155 (Satterwhite and Boudinot, 1992) | 70 ± 12 | 2.2 |
| Prazosin | 196 (Ohkura et al., 1999) | 45 ± 0.76 | 4.3 |
| Bosentan | 1916 (Huang et al., 2012) | 79 ± 0.05 | 24 |