TABLE 2

The unbound fractions (fu) for the enantiomers of fluoxetine and norfluoxetine in pooled HLMs at 0.1 mg/ml and 1.0 mg/ml microsomal protein and in plasma

fu,HLMfu,plasma
0.1 mg/ml1.0 mg/ml
(R)-Fluoxetine0.480.090.22
(S)-Fluoxetine0.520.100.14
(R)-Norfluoxetine0.420.070.20
(S)-Norfluoxetine0.470.070.13