TABLE 2

Scaling up of in vitro intrinsic clearance (from Table 1) to in vivo hepatic clearance

EthanolCLint, vitroaCLint, vivoCLHbEH
%µl/min/mgml/min/kg
057559512.10.55
0.2551753511.50.52
0.545246810.80.49
13823959.80.45
23143258.80.40

  • ↵a CLint, vitro calculated as sum of CLint and CLint2 (Table 1).

  • ↵b Using fu = 0.045.