TABLE 1
Kinetic parameters for hydrolysis of three ACE inhibitors by recombinant human CES1
Substrate
K
m
V
max
K
si
CL
int
µ
M
nmol/min/mg protein
µ
M
ml/min/mg protein
Trandolapril
1734
624
—
0.360
Ramipril
901
956
—
1.061
Enalapril
1721
34
2956
0.020