TABLE 2

Pharmacokinetic parameters of tacrolimus (FK506) after a single intravenous dose of tacrolimus (0.2 mg/kg) in rats with and without an oral dose of schisandrol B (0.024 mM/kg). Data are the mean ± S.D. (n = 4).

GroupFK506 Alone+ Schisandrol B
AUC0-24 (ng/ml·h)109.0 ± 13.5151.3 ± 20.8
AUC0-∞ (ng/ml·h)132.0 ± 14.2176.7 ± 22.4
CLiv (l/h/kg)1.5 ± 0.21.2 ± 0.1
Vd (l/kg)16.1 ± 1.511.3 ± 1.9
t1/2 (h)6.8 ± 0.66.9 ± 0.9
MRT (h)6.5 ± 0.36.3 ± 0.4
  • CLiv, total intravenous blood clearance; MRT, mean residence time; t1/2, terminal half-life; Vd, volume of distribution.