TABLE 3

Summary of derived pharmacokinetic parameters of tacrolimus (FK506) after a single oral dose (1.89 mg/kg) or intravenous dose (0.2 mg/kg) of tacrolimus in rats with and without an oral dose of schisandrol B (0.024 mM/kg)

GroupFK506 AloneWith Schisandrol B
fu×CLint (l/h/kg)2.84 ± 0.541.69 ± 0.33*
Foral (%)5.40 ± 2.7427.45 ± 10.53***
ERH0.46 ± 0.050.34 ± 0.04**
FH0.54 ± 0.050.66 ± 0.04**
Fabs×FG0.10 ± 0.0090.41 ± 0.03***
  • Fabs×FG, gut processes affecting availability; fu×CLint, Total drug intrinsic clearance.

  • * P < 0.05; **P < 0.005; ***P < 0.0005, significant difference as compared with the FK506 alone group.