Metabolite | Formation Rates (pmol/min per total liver) | % of the Formation of M2a, M2b, and Faldaprevir Glucuronide | ||
---|---|---|---|---|
In Vitro Rat HepatoPac Data | In Vivo Rat Data | In Vitro Rat HepatoPac Data | In Vivo Rat Data | |
M2a | 16.4 | 7.7 | 1.5 | 3.1 |
M2b | 24.9 | 6.1 | 2.2 | 2.5 |
Faldaprevir glucuronide | 1081 | 232 | 96 | 94 |
Fold of formation rates (glucuronide vs. M2a + M2b) | 26 | 17 | — | — |
—, not applicable.