Association of MRP4 inhibition and type of liver injury
Compounds were defined as MRP4 inhibitors at a concentration of 100 μM based on a cutoff of 21% for inhibition of MRP4-mediated transport to predict cholestatic potential. χ2 test P values are shown.
| MRP4 Inhibition | |||
| BSEP Non-inhibitors (n = 50) | |||
| Cholestatic | Non-cholestatic | P value | |
| MRP4 non-inhibitors | 10 | 20 | |
| 0.0016 | |||
| MRP4 inhibitor | 16 | 4 | |
| BSEP Inhibitors (n = 38) | |||
| Cholestatic | Non-cholestatic | P value | |
| MRP4 non-inhibitors | 1 | 4 | |
| 0.14 | |||
| MRP4 inhibitor | 21 | 12 | |