TABLE 2

Recovery of tofacitinib, metabolites, and total radioactivity in urine and feces following a single oral dose of 14C-tofacitinib 50 mg (n=6)

All values correspond to mean (S.D.).

AnalyteRecovery in UrineRecovery in FecesTotal Recovery
% Dose
Total radioactivity80.1 (3.6)13.8 (1.9)93.9 (3.6)
Tofacitinib28.8 (7.1)0.9 (0.8)29.7
M1/M23.6 (0.3)ND3.6
M2ND0.5 (0.1)0.5
M48.2 (1.2)ND8.2
M4/M18ND3.4 (0.9)3.4
M81.4 (0.5)ND1.4
M919.6 (2.2)1.6 (0.4)21.2
M11ND1.5 (0.3)1.5
M11/M2910.6 (1.9)ND10.6
M143.5 (0.9)1.9 (0.3)5.4
M202.2 (0.7)ND2.2
M22ND1.8 (0.4)1.8
M311.4 (0.5)ND1.4
UnknownND2.2 (0.6)2.2
  • ND, not detected.