Inhibitor | % Inhibition | |
---|---|---|
Odanacatib 1 µM | Odanacatib 10 µM | |
mAbs | ||
Anti-CYP1A2 | 14.9 | 0.0 |
Anti-CYP2A6 | 5.4 | 0.0 |
Anti-CYP2C | 9.2 | 4.3 |
Anti-CYP2D6 | 13.3 | 0.0 |
Anti-CYP3A4 | 93.5 | 88.4 |
Combination mAbs | ||
Anti-CYP3A4 + anti-CYP2C | 98.3 | NS |
Anti-CYP3A4 + anti-CYP2C8 | 97.3 | NS |
Anti-CYP3A4 + anti-CYP2C9 | 90.6 | NS |
Anti-CYP3A4 + anti-CYP2D6 | 92.0 | NS |
Chemical inhibitors | ||
Sulfaphenazole | 0.0 | 2.2 |
Ketoconazole | 95.3 | 92.2 |
Quinidine | 11.3 | 9.5 |
Quercetin | 23.3 | 23.4 |
N-3-benzyl-phenobarbital | 2.0 | 6.8 |
Triacetyloleandomycina | 92.6 | 87.3 |
Furafyllinea | 0.0 | 2.7 |
NS, not studied.
↵a Time-dependent inhibitors.