TABLE 1

Percentage of the radioactive dose recovered in urine and feces following an oral dose of [14C]odanacatib to healthy volunteers

Time point (h)	Subject						Mean	S.D.
Time point (h)	441	442	443	444	445	446	Mean	S.D.
Urine
0–24	1.45	2.43	3.97	2.21	1.81	2.03	2.32	0.88
24–48	2.56	2.42	3.29	3.79	1.74	4.88	3.08	1.25
48–72	1.77	1.93	2.20	2.64	2.05	2.95	2.27	0.50
72–96	1.38	1.54	1.47	1.93	1.49	2.67	1.80	0.53
96–120	1.12	1.38	1.09	1.41	1.85	1.99	1.55	0.36
120–144	0.81	0.88	0.68	1.14	1.54	1.50	1.17	0.34
144–168	0.61	0.80	0.67	0.69	1.15	1.09	0.87	0.24
168–480	2.92	2.99	1.88	2.85	5.82	5.27	3.62	1.55
480–816	0.10	BLQ	BLQ	NC	0.78	0.26	0.19	0.31
Total	12.7	14.4	15.3	16.7	18.2	22.6	16.9	3.8
Feces^{^a}
0–24	BLQ	0.03	BLQ	NS	NS	NS	0.01	0.01
24–48	42.8	45.8	NS	20.2	0.25	24.4	26.7	18.5
48–72	16.0	10.1	13.5	16.6	3.34	NS	9.21	7.43
72–96	7.76	3.40	NS	25.7	9.17	23.2	13.8	10.0
96–120	4.13	2.76	1.78	6.59	17.4	5.10	7.20	5.87
120–144	NS	2.05	NS	NS	NS	NS	0.41	0.92
144–168	4.30	2.69	0.95	4.14	19.5	7.31	7.59	6.87
168–336	5.24	5.10	1.96	3.80	10.62	7.71	6.49	2.71
336–504	0.93	2.25	0.67	0.96	5.87	1.87	2.38	2.04
504–816	0.23	0.90	BLQ	NC	1.44	0.64	0.64	0.57
Total	81.4	75.1	18.9	78.0	67.6	70.2	74.5	5.6
Urine + feces	94.1	89.5	34.1	94.7	85.8	92.9	91.4	3.7

BLQ, below the limit of quantification; NC, no collection of sample (subject exited study); NS, no sample.
↵a The fecal recovery of subject 443 was significantly lower than for other subjects, and thus data for this subject were not included in the calculation of mean values. Two early samples (24–48 and 72–96 hours), in which a high percentage of the dose would be expected based on the pattern observed with the other subjects, were not available from this subject.