Subject | Odanacatib | Radioactivity | Odanacatib:Radioactivity | ||||||
---|---|---|---|---|---|---|---|---|---|
AUC0–∞ | Cmax | Tmax | Apparent Terminal t1/2 | AUC0–∞ | Cmax | Tmax | AUC0–∞ | Cmax | |
μM · h | nM | h | h | μM · h | nM | h | Ratio | Ratio | |
441 | 16.91 | 214.0 | 12 | 89.1 | 34.10 | 241.0 | 12 | 0.50 | 0.89 |
442 | 26.12 | 218.9 | 8 | 150.3 | 41.30 | 258.0 | 24 | 0.63 | 0.85 |
443 | 17.39 | 314.5 | 5 | 92.0 | 33.00 | 337.0 | 5 | 0.53 | 0.93 |
444 | 15.34 | 261.3 | 12 | 81.9 | 37.10 | 299.0 | 12 | 0.41 | 0.87 |
445 | 21.13 | 174.2 | 24 | 86.1 | 39.50 | 206.0 | 24 | 0.53 | 0.85 |
446 | 22.38 | 281.8 | 24 | 105.5 | 46.40 | 346.0 | 24 | 0.48 | 0.81 |
AM | 19.88 | 244.1 | 14.2 | 96.7a | 38.57 | 281.2 | 16.8 | 0.51 | 0.87 |
S.D. | 4.06 | 51.19 | 8.1 | 18.3b | 4.96 | 55.57 | 8.3 | 0.07 | 0.04 |