TABLE 5

Percentage of combined metabolite formation of tofacitinib in recombinant human P450 isoforms

Recombinant enzyme concentrations used were 25 pmol/1 ml for 30 minutes and 50 pmol/1 ml for 2 hours.

Recombinant Human P450 Isoform Relative % Metabolite Formation
Observation Time1A11A22A62B62C82C92C182C192D62E13A43A5
30 min4.53.41.51.51.30.91.810.64.41.329.8NA
2 hNA9.5NANANTNTNA43.98.8NT83.615.9
  • NA, not available; NT, no significant turnover detected.