Mean pharmacokinetic parameters of total radioactivity in mice, rats, dogs, and humans
| Species | Sex | No. of Subjects | Dose | Cmax | Tmax (h) | AUC0–∞ |
|---|---|---|---|---|---|---|
| μg/ml | h | μg⋅h/ml | ||||
| Mouse | Male | 4 | 100 mg/kg | 29.9 | 7 | 451 |
| Female | 4 | 100 mg/kg | 34.79 | 4 | 498 | |
| Rat | Male | 4 | 3 mg/kg | 1.21 | 8 | 17.7 |
| Female | 4 | 3 mg/kg | 0.933 | 4 | 12.1 | |
| Dog | Male | 3 | 4 mg/kg | 5.49 | 1 | 87.3 |
| Human | Male | 6 | 188 mg | 3.74 | 2a | 28.2 |
AUC, area under the curve.
↵a Median value.