Relative distribution of metabolites in pooled plasma from mice, rats, dogs, and humans after oral administration of [14C]canagliflozin
| Metabolite Identification | %Sample Radioactivitya | |||||
|---|---|---|---|---|---|---|
| Mouse (100 mg/kg) | Rat (3 mg/kg) | Dog (4 mg/kg) | Human (188 mg) | |||
| Male | Female | Male | Female | Male | Male | |
| Canagliflozin | 94.2 | 93.9 | 98.2 | 98.6 | 98.7 | 61.8 |
| M5 | ND | ND | ND | ND | ND | 19.2 |
| M7 | 2.6 | 1.6 | ND | ND | ND | 13.6 |
| M9 | 1.6 | 2.2 | ND | ND | ND | 3.1 |
| Total | 98.4 | 97.7 | 98.2 | 98.6 | 98.7 | 97.7 |
ND not detected.
↵a Plasma samples pooled over 0–24 h.