TABLE 1

The recombinant UGT isoforms responsible for acyl-glucuronidations of NSAIDs in humans

NSAIDConcentrationGlucuronidation Activity of Recombinant UGT IsoformsReference
μM
Diclofenac5002B7 > 1A3 > 2B17 > 1A9 > 2B15 > 1A6Kuehl et al., 2005
Edotolac501A9 > 1A10 ≥ 2B7Tougou et al., 2004
Ibuprofen5002B7 > 1A3 > 1A9 > 2B4Kuehl et al., 2005
Ketoprofen5002B7 > 2B4 > 1A3 > 1A9Kuehl et al., 2005
Indomethacin5001A9 > 2B7 > 1A3 > 1A1Kuehl et al., 2005
Naproxen5002B7 > 1A3 > 1A9 > 2B4Kuehl et al., 2005