P450 | %P450 Contributiona Based on Metabolite Formation | %P450 Contributionb Based on Substrate Depletion |
---|---|---|
1A2 | 0 | 1.9 |
2C8 | 67 | 56 |
2C9 | 4.0 | 10 |
2C19 | 5.0 | 1.5 |
2D6 | 0 | 0.4 |
3A4 | 24 | 23 |
↵a Values represent the normalized (scaled) rates of total metabolite formation (expressed as a percentage) of individual P450s with respect to the total normalized metabolite rates from the reaction phenotyping study.
↵b Values represent the normalized (scaled) rates of parent depletion (expressed as a percentage) of individual P450s with respect to the total normalized rates from the intrinsic clearance study.