TABLE 3

Pharmacokinetic parameters after i.v. (5 mg/kg) and PO (15 mg/kg) administrations of rosuvastatin to FVB WT, Oatp1a/1b KO, hOATP1B1, and hOATP1B3 mice

Values are presented as the mean ± S.D. (n = 4).

Mouse Linei.v. AdministrationPO Administration
CLAUC0-24hrAUC0-24hrCmax
ml/min/kgµM*hµM*hµM
FVB WT88.8 ± 28.0a2.45 ± 0.96a0.08 ± 0.02a0.04 ± 0.02a
Oatp1a/1b KO31.2 ± 7.205.73 ± 1.583.80 ± 0.951.39 ± 0.50
hOATP1B129.5 ± 12.27.02 ± 2.334.09 ± 0.933.30 ± 1.77
hOATP1B328.5 ± 9.97.35 ± 3.413.14 ± 0.850.75 ± 0.12a
  • AUC0-2hr, Area under the plasma concentrations-time curve from time 0 to 2 hours; CL, Plasma clearance.

  • a Significantly different from Oatp1a/1b KO mice (P < 0.05).