TABLE 2

Pharmacokinetic parameters after 5 mg/kg PO administration of pitavastatin to FVB WT (n = 12), Oatp1a/1b KO, hOATP1B1, and hOATP1B3 mice (n = 9 for all three lines)

PK calculations were performed as a group analysis due to the experimental design (see Materials and Methods).

Mouse LinePO Administration
AUC0-8hrCmax
µM*hµM
FVB WT0.33 ± 0.10.39 ± 0.17
Oatp1a/1b KO3.87 ± 0.555.27 ± 2.64
hOATP1B13.70 ± 0.924.59 ± 1.12
hOATP1B34.01 ± 0.476.91 ± 0.63