TABLE 1

Pharmacokinetic parameters after i.v. and PO administrations of 5 mg/kg pravastatin to FVB WT, Oatp1a/1b KO, hOATP1B1, hOATP1B3, and hOATP1B1/1B3 mice

Values are reported as the mean ± S.D. (n = 4 mice).

Mouse Line	i.v. Administration		PO Administration
Mouse Line	CL	AUC_0-2hr	AUC_0-2hr	C_max
	ml/min/kg	µMh*	µMh*	µM
Study 1
FVB WT	150 ± 22^{^a}	1.32 ± 0.20^{^a}	0.045 ± 0.01^{^a}	0.07 ± 0.04^{^a}
Oatp1a/1b KO	36 ± 2.8	5.46 ± 0.40	0.81 ± 0.33	0.68 ± 0.35
hOATP1B1	45 ± 9.1	4.50 ± 0.81	0.39 ± 0.06^{^a}	0.39 ± 0.14
hOATP1B3	56 ± 7.4^{^a}	3.55 ± 0.48^{^a}	0.17 ± 0.06^{^a}	0.16 ± 0.05^{^a}
Study 2
FVB WT	132 ± 8.9^{^a}	1.49 ± 0.11^{^a}	NC	NC
Oatp1a/1b KO	39 ± 3.6	5.07 ± 0.48	0.86 ± 0.22	0.74 ± 0.18
hOATP1B1/1B3	83 ± 13^{^a}	2.39 ± 0.36^{^a}	0.23 ± 0.04^{^a}	0.22 ± 0.07^{^a}

AUC_0-2hr, Area under the blood concentrations-time curve from time 0 to 2 hours; CL, Blood clearance; NC, not calculated.
↵^a Significantly different from Oatp1a/1b KO mice (P < 0.05).