Kinetic parameters of lenvatinib and M2 metabolized by AO in human liver cytosol
Data represent the mean ± S.D. of triplicate determinations. Kinetic parameters are calculated using the substrate inhibition model.
| Parameter | Lenvatinib | M2 |
|---|---|---|
| Km (μM) | 161.5 ± 62.5 | 1.7 ± 0.2 |
| Vmax (pmol/min/mg) | 73.0 ± 22.2 | 269.8 ± 10.1 |
| Ki (μM) | 177.6 ± 96.6 | 239.8 ± 71.6 |
| CLint (Vmax/Km, ml/min/mg) | 2.2 | 163.9 |