Enzyme | CYP1A2 | CYP2A6 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C18 | CYP2C19 | CYP2D6 | CYP2E1 | CYP2J2 | CYP3A4 | CYP3A5 | CYP3A7 | CYP3A43 | CYP4F2 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|

CYP1A2 | 1 | Rs = 0.50^{a} | — | Rs = 0.34 | Rs = 0.56^{a} | — | — | — | — | Rs = 0.58^{a} | Rs = 0.38 | — | — | — | — |

P = 0.0002 | P = 0.003 | P < 0.0001 | P = 0.003 | P = 0.0006 | |||||||||||

n = 51 | n = 72 | n = 53 | n = 24 | n = 80 | |||||||||||

CYP2A6 | 1 | Rs = 0.47 | Rs = 0.64^{b} | Rs = 0.64^{b} | — | Rs = 0.52^{a} | — | — | — | Rs = 0.58^{a} | — | — | — | — | |

P = 0.0005 | P < 0.0001 | P < 0.0001 | P = 0.006 | P < 0.0001 | |||||||||||

n = 51 | n = 51 | n = 50 | n = 27 | n = 50 | |||||||||||

CYP2B6 | 1 | Rs = 0.40 | — | — | — | — | — | — | Rs = 0.46 | — | — | — | — | ||

P = 0.0036 | P < 0.0001 | ||||||||||||||

n = 51 | n = 124 | ||||||||||||||

CYP2C8 | 1 | Rs = 0.55^{a} | — | Rs = 0.37 | Rs = 0.61^{b} | — | — | Rs = 0.68^{b} | — | — | — | — | |||

P < 0.0001 | P = 0.001 | P < 0.0001 | P < 0.0001 | ||||||||||||

n = 99 | n = 61 | n = 51 | n = 134 | ||||||||||||

CYP2C9 | 1 | Rs = 0.57^{a} | Rs = 0.40 | — | — | — | Rs = 0.55^{a} | — | — | — | — | ||||

P = 0.005 | P < 0.0001 | P < 0.0001 | |||||||||||||

n = 23 | n = 419 | n = 71 | |||||||||||||

CYP2C18 | 1 | — | — | — | — | — | — | — | Rs = 0.62^{b} | — | |||||

P = 0.002 | |||||||||||||||

n = 23 | |||||||||||||||

CYP2C19 | 1 | Rs = 0.53^{a} | — | — | — | — | — | — | — | ||||||

P = 0.005 | |||||||||||||||

n = 27 | |||||||||||||||

CYP2D6 | 1 | — | — | — | — | Rs = 0.51^{a} | — | — | |||||||

P = 0.002 | |||||||||||||||

n = 36 | |||||||||||||||

CYP2E1 | 1 | — | — | — | — | — | — | ||||||||

CYP2J2 | 1 | — | — | — | — | — | |||||||||

CYP3A4 | 1 | Rs = 0.70^{*}^{, }^{b} | — | — | — | ||||||||||

P < 0.0001^{*} | |||||||||||||||

n = 52^{*} | |||||||||||||||

CYP3A5 | 1 | — | — | — | |||||||||||

CYP3A7 | 1 | — | — | ||||||||||||

CYP3A43 | 1 | ||||||||||||||

CYP4F2 | 1 |

Spearman correlation (

*R*s) analysis was used. Significant strong correlations are in bold font and significant strong correlations are shown in italic bold font. Nonsignificant correlations are not included (—).*R*s, the Spearman correlation coefficient;*P*, probability value;*n*, number of subjects.↵

^{a}*R*s between 0.50 and 0.59;^{b}*R*s of .60 and above.↵* Correlation between CYP3A4 and CYP3A5*1/*3 abundance data from nine studies.