TABLE 2

Correlations matrix of the abundance data of 15 cytochrome P450 enzymes from 32 studies

EnzymeCYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C18CYP2C19CYP2D6CYP2E1CYP2J2CYP3A4CYP3A5CYP3A7CYP3A43CYP4F2
CYP1A21Rs = 0.50aRs = 0.34Rs = 0.56aRs = 0.58aRs = 0.38
P = 0.0002P = 0.003P < 0.0001P = 0.003P = 0.0006
n = 51n = 72n = 53n = 24n = 80
CYP2A61Rs = 0.47Rs = 0.64bRs = 0.64bRs = 0.52aRs = 0.58a
P = 0.0005P < 0.0001P < 0.0001P = 0.006P < 0.0001
n = 51n = 51n = 50n = 27n = 50
CYP2B61Rs = 0.40Rs = 0.46
P = 0.0036P < 0.0001
n = 51n = 124
CYP2C81Rs = 0.55aRs = 0.37Rs = 0.61bRs = 0.68b
P < 0.0001P = 0.001P < 0.0001P < 0.0001
n = 99n = 61n = 51n = 134
CYP2C91Rs = 0.57aRs = 0.40Rs = 0.55a
P = 0.005P < 0.0001P < 0.0001
n = 23n = 419n = 71
CYP2C181Rs = 0.62b
P = 0.002
n = 23
CYP2C191Rs = 0.53a
P = 0.005
n = 27
CYP2D61Rs = 0.51a
P = 0.002
n = 36
CYP2E11
CYP2J21
CYP3A41Rs = 0.70*, b
P < 0.0001*
n = 52*
CYP3A51
CYP3A71
CYP3A431
CYP4F21
• Spearman correlation (Rs) analysis was used. Significant strong correlations are in bold font and significant strong correlations are shown in italic bold font. Nonsignificant correlations are not included (—). Rs, the Spearman correlation coefficient; P, probability value; n, number of subjects.

• a Rs between 0.50 and 0.59; bRs of .60 and above.

• * Correlation between CYP3A4 and CYP3A5*1/*3 abundance data from nine studies.