TABLE 4

CLint values in intestinal S9 of human, monkey, dog, and rat

Each value presents the mean ± S.D. (n = 3).

No.CompoundsCLint,IS9
HumanMonkeyDogRat
ml/min/mg S9 protein
1Benazeprila0.019 ± 0.0063a0.0069 ± 0.00068
2Cilazaprila0.073 ± 0.014a0.025 ± 0.0056
3Quinaprila0.0074 ± 0.0027a0.0041 ± 0.00084
4Trandolaprilaaa0.0037 ± 0.00021
5Perindoprila0.0072 ± 0.0016aa
6Ramiprila0.0035 ± 0.0013a0.0060 ± 0.00037
7Temocaprila15 ± 2.5a0.34 ± 0.12
8Oseltamiviraaaa
9Candesartan cilexetil2.9 ± 0.693.3 ± 1.18.0 ± 1.90.77 ± 0.46
10Mycophenolate mofetil0.83 ± 0.09614 ± 3.00.0069 ± 0.00210.23 ± 0.063
11Olmesartan medoxomil0.40 ± 0.0470.24 ± 0.0350.047 ± 0.0200.20 ± 0.037
  • a CLint values could not be obtained. The remaining ratio of the compounds incubated for 60 minutes was >90%. (CLint < 0.002 ml/min/mg S9 protein).