Pharmacokinetic parameters of plasma nicotine and metabolites in EA and AD rats following s.c. nicotine
Data are presented as mean (S.D.).
| Parameter | NIC | COT | NNIC | NNO | ||||
|---|---|---|---|---|---|---|---|---|
| EA | AD | EA | AD | EA | AD | EA | AD | |
| Cmax (ng/ml) | 217 (37) | 253 (65) | 206 (73) | 361 (112) | 13** (2.5) | 9 (1.8) | 66** (23) | 105 (8.4) |
| t1/2 (min) | 62 | 74 | 446 | 543 | 123 | 181 | 66 | 89 |
| AUC(10min–4h) (ng⋅h/ml) | 278*** (29) | 479 (56) | 658** (52) | 960 (55) | 39*** (1.7) | 26 (1.7) | 144*** (9.4) | 255 (12) |
| AUC(2–8h) (ng⋅h/ml) | 87* (29) | 249 (47) | 988* (193) | 1893 (272) | 37 (4.8) | 34 (6.8) | 66** (16) | 148 (20) |
COT, cotinine; NIC, nicotine; NNIC, nornicotine; NNO, nicotine-1′-N-oxide.
↵* P < 0.05, **P < 0.01, ***P < 0.001 versus AD(s.c.) group.