TABLE 1

Accurate mass data for lovastatin and its metabolites

CompoundRTElemental compositionTheoretical MassMeasured MassErrorRemark
Da
Lovastatin15.4C24H36O5Na+427.2482427.24400.7HF, RF, HLM, RLM
M113.6C19H28O4H+321.2060321.20480.6HF, RF, RP
M214.7C24H34O5Na+425.2326425.23211.2HLM, RLM
M39.0C24H36O6Na+443.2404443.24275.2HLM, RLM
M49.4C24H36O6Na+443.2404443.24224.1HF, RF, HLM, RLM
M511.5C24H36O6Na+443.2404443.24265.0RLM
M613.0C24H36O6Na+443.2404443.24254.7RP, HLM
M714.1C24H36O6Na+443.2404443.24244.5HLM
M813.6C24H38O6Na+445.2584445.25844.9HF, RF, HLM, RLM, RP
M95.4C24H38O7Na+461.2510461.24982.6HF, RF, HLM, RLM
M107.3C24H38O7Na+461.2510461.25355.4HLM
M118.2C24H38O7Na+461.2510461.25386.1HLM, RLM, RP
  • HF, human feces; RF, rat feces; HLM, human liver microsomes; RLM, rat liver microsomes; RP, rat plasma.