Study compounds
| Compound | Top Assay Concentration (ยตM) | Mechanisms of Toxicity | Cytochrome P450 Metabolism |
|---|---|---|---|
| Amiodarone | 125 | Mitochondrial toxicity (Kaufmann et al., 2005) | CYP1A1, CYP3A4 (Elsherbiny et al., 2008) |
| Aflatoxin B1 | 140 | DNA adductor causing mutations and reactive oxygen species formation (Do and Choi, 2007) | CYP3A4, CYP1A2 (Guengerich et al., 1996) |
| Troglitazone | 125 | Idiosyncratic hepatotoxic, impaired mitochondria function (Jaeschke, 2007) | CYP3A (Kassahun et al., 2001) |
| Ximelagatran | 400 | Unknown hepatotoxic mechanism, connected to raised aminotransferase levels (Lee et al., 2005) | None of the major P450s are involved in the metabolism (Bredberg et al., 2003; Clement and Lopian, 2003) |