Accuracy of the predicted human CLh of six CYP3A4 substrates based on the correlation of CLint,h between human and Tg mice compared with observed values
| Substrate | CLh | Accuracy | |
|---|---|---|---|
| Observed | Predicted | ||
| ml/min per kg | % | ||
| Alprazolam | 1.03 | 2.01 | 195 |
| Felodipine | 16.4 | 17.3 | 106 |
| Midazolam | 7.26 | 10.7 | 147 |
| Nifedipine | 5.82 | 2.98 | 51 |
| Nitrendipine | 12.3 | 11.2 | 92 |
| Quinidine | 4.14 | 2.65 | 64 |