Pharmacokinetic parameters of lovastatin hydroxy acid in control and antibiotic-treated rats (n = 10)
| Control | Ampicillin | Antibiotic Mixture | |
|---|---|---|---|
| Cmax (ng/ml) | 188.1 ± 67.8 | 114.7 ± 26.0* | 93.12 ± 78.0* |
| Tmax (hour) | 2.2 ± 2.2 | 1.9 ± 2.3 | 1.8 ± 1.3 |
| AUC (ng·h/ml) | 907.9 ± 309.7 | 589.3 ± 117.6** | 448.4 ± 143.7** |
↵* P < 0.05, **P < 0.01.