TABLE 3

Literature reports of aldehyde oxidase-mediated metabolism in cynomolgus monkey

SubstrateMetabolic PathwayMetaboliteMatrixReference
ZaleplonOxidation of pyrazolo-pyrimidine5-Oxo zaleplonLiver S9 fractionKawashima et al., 1999
SB-277011Oxidation of quinolineSB-369912Liver homogenateAustin et al., 2001
RS-8359Oxidation of pyrimidine2-Keto RS-8359Liver cytosolItoh et al., 2006
ZebularineOxidation of pyrimidineUridineLiver cytosolKlecker et al., 2006
VanillinVanillic acid formationVanillic acidLiver cytosol, hepatocytesSahi et al., 2008
SGX523Oxidation of quinolineM11Liver S9 fraction, plasma, urineDiamond et al., 2010
VU0409106Oxidation of pyrimidineM1HepatocytesMorrison et al., 2012
ZoniporideOxidation of quinoline2-Oxo zoniporideLiver S9 fractionDalvie et al., 2013