TABLE 2

Pharmacokinetic properties of BIBX1382 in human and male cynomolgus monkey

Data are reported as a range (human) or as mean (S.D.) from n = 3 monkeys.

Species	Subjects	Route	Dose	Plasma Clearance ml/min per kg (S.D.)	Volume of Distribution L/kg (S.D.)	C_max nM (S.D.)	AUC nM*h (SD)	Absolute Bioavailability % (range)
Human^a	11 (4M, 7F)	i.v. infusion	25–200 mg	25-55	10-20	—	8.5–34.5	—
Human^a	11 (4M, 7F)	p.o.	25–200 mg	—	—	0.03–0.41	0.1–2.5	5 (2–12)
Cynomolgus Monkey^b	3 (M)	i.v. bolus	1 mg/kg	118 (28)	39 (6)	—	350 (80)	—
Cynomolgus Monkey^b	3 (M)	p.o.	2 mg/kg	—	—	12.7 (3.8)	43 (25)	6 (3–10)

C_max, maximal plasma concentration; AUC, area under the concentration-time curve; M, male; F, female.
↵^a Data reported in Dittrich et al., 2002 [C_max and AUC_(0–24) values are dose normalized].
↵^b AUC reported as AUC_last.