TABLE 2

Tissue exposure of IR800-8C2 compared with [¹²⁵I]8C2.

Tissue	AUC (IR800)^{^a}	AUC (¹²⁵I)	AUC (IR800)/AUC (¹²⁵I)	TB (IR800)/TB (¹²⁵I)^{^b}
	nMday*	nMday*
Liver	636.1 (69)	483.7 (57.1)	1.32	3.24
Spleen	117.1 (15.5)	560.5 (56.9)	0.21	0.52
Lung	213.6 (13.9)	656.4 (65.1)	0.33	0.80
Heart	41.0 (6.6)	406.8 (33.3)	0.10	0.25
Kidney	130.1 (23)	505.5 (45.6)	0.26	0.63
Skin	80.1 (0.5)	630.8 (27.8)	0.13	0.31
Muscle	21.3 (1.4)	1889.9 (7.9)	0.11	0.28
Bone	61.2 (3.3)	324.9 (15.2)	0.19	0.46
GI	56.2 (3.1)	350.3 (101.3)	0.16	0.39

↵^a AUC determined directly by IR800 fluorescence.
↵^b TB represents the tissue-to-blood ratio. Parameters are derived from triplicate measurements with average and (standard deviation) reported.