UGT Isoform | Substrate | Inhibitor | IC50 | Reported IC50 | Reference | |
---|---|---|---|---|---|---|
Individual Substrate | Cocktail Substrate | |||||
µM | ||||||
UGT1A1 | β-Estradiol | Bilirubin | 22.5 | 31.5 | 4.0 and 30 | Williams et al., 2002; Tachibana et al., 2005 |
UGT1A3 | Chenodeoxycholic acid | Lithocholic acid | 4.8 | 12.3 | —a | — |
UGT1A4 | Trifluoperazine | Hecogenin | 2.2 | 3.2 | 1.5 and 15 | Uchaipichat et al., 2006; Edavana et al., 2013 |
UGT1A6 | 4-Hydroxyindole | Troglitazone | 195.5 | 185.8 | 28 | Ito et al., 2001 |
UGT1A9 | Propofol | Niflumic acid | 0.3 | 0.2 | 0.034 and 0.4 | Mano et al., 2006; Miners et al., 2011 |
UGT2B7 | Naloxone | Fluconazole | 5100 | 5100 | 1790 and 2500 | Mano et al., 2007; Donato et al., 2010 |
↵a Data not available.