Intrinsic clearance (CLint) values for CYP2C76 substrates
| Compound | CLint (ml/min per nmol P450) | ||||
|---|---|---|---|---|---|
| CYP2C9 | CYP2C19 | CYP2C76 | CYP3A4 | CYP2B6 | |
| Pitavastatin lactonea | 3.36 | 0.85 | 0.43 | ND | ND |
| Nifedipine | 0.67 | 0.23 | 4.23 | 6.57 | ND |
| Bupropion | <0.10 | <0.10 | 0.47 | ND | 0.19 |
ND, not determined
↵a Pitavastatin lactone was used as positive control because CYP2C76 is important for monkey-specific metabolism of pitavastatin lactone (Uno et al., 2007).