Major metabolic clearance mechanisms involved in the elimination of drugs

Clearance MechanismPossible Enzymes/Proteins Involved
Oxidative metabolismP450, AO, FMO, MAO, Mo-CO, peroxidases
Conjugative metabolismUGT, ST, GST, NAT, methyl transferase
Hydrolytic metabolismEsterases, amidases, epoxide hydrolase, P450
Reductive metabolismP450, ketoreductase, Mo-CO
  • FMO, flavin monooxygenase; GST, glutathione S-transferase; MAO, monoamine oxidase; Mo-CO, molybdenum cofactor; NAT, N-acteyl transferase; ST, sulfotransferase.