Suppression of gene expression for CYP1A2, CYP2B6, and CYP3A4 after treating primary hepatocytes with increasing concentrations of IL-6 (0.006–50 ng/ml) and IL-18 (1.95–500 ng/ml)

Data were normalized to untreated cells and fitted to a four-parameter dose-response model. Mean and standard deviation values are from two different wells. For IL-18, no Emin is quoted owing to the lack of any dose-response.

EnzymeIL6IL18 EC50
% of controlng/ml
CYP1A219.3 ± 9.465.49>500
CYP2B622.4 ± 2.270.177>500
CYP3A47.65 ± 3.430.454>500